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Ako Orlistat účinkuje ako liek na chudnutie

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1.Weight Loss Drug History

Prvé lieky na zníženie hmotnosti, ktoré sa v tom čase označovali ako redukčné tuky, sa stali dostupnými v neskorých 1800. Hoci táto droga spôsobila niektoré závažné vedľajšie účinky, aj naďalej bola k dispozícii až do použitia 1960.

Nové lieky známe ako Dinitrophenol boli zavedené do 1930 a stali sa veľmi populárne pri riadení chudnutia. Liečivo vyvolalo termogénny účinok v tele, ktoré uľahčuje úbytok hmotnosti.

V polovici-1950s, amfetamíny sa stali dostupnými a ukázalo sa, že liekom na chudnutie voľby. Uľahčuje úbytok hmotnosti tým, že potláča chuť do jedla. Bohužiaľ, zvýšilo riziko pľúcnej hypertenzie, čo viedlo k jeho stiahnutiu z trhu v spoločnosti 1968.

V 1970 sa efedrín stal predpísaným liekom na úbytok hmotnosti. Liek však vyvolal niektoré nežiaduce reakcie, ktoré viedli k tomu, že bola vyhlásená za nebezpečnú látku.

V prípade 1973 sa fenfluramín schválil ako doplnok na zníženie telesnej hmotnosti. Jeho obľúbenosť stúpala v 1992, keď bola kombinovaná s fentermínom na vytvorenie lieku na zníženie telesnej hmotnosti známej ako fen-fen. Je zrejmé, že droga spôsobila niektoré nepriaznivé účinky, čo viedlo k jej stiahnutiu z trhu v spoločnosti 1997. V 21st storočia, drogy na zníženie hmotnosti, veľa založené na rastlinných prípravkoch, zaplavilo trh.

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2.Weight Loss Drug Classification

Lieky na úbytok hmotnosti sú rozdelené do troch hlavných kategórií podľa ich mechanizmu účinku a sú tieto:

 

(1) potláčajúca chuť do jedla (diéta)

Lieky, ktoré znižujú príjem potravy, sa nazývajú sympatomimetiká. Zvyčajne potláčajú chuť do jedla, pričom indukujú sýtosť skôr ako zvyčajne. Satiety je "plný" pocit alebo spokojnosť získaná pri podávaní potravy. Funkcia potláčajúca chuť do jedla funguje napodobovaním neurotransmitera v ľudskom mozgu, ktorý kontroluje chuť do jedla, známy ako noradrenalín (NA).

 

These drugs share a similar chemical structure with NA and can; as a result bind to the same receptors as noradrenaline. The drugs also improve noradrenaline activity in the “feeding center” of the human brain, the hypothalamus. The human hypothalamus controls the energy balance in the body system. The information about individual energy stores is synthesized in the hypothalamus which regulates food intake and appetite. Noradrenaline binding and activity in the hypothalamus has a reducing effect on appetite. Such drugs include:

❶ Lorcaserin HCL(Belviq) CAS: 1431697-94-7

❷ Rimonabant HCL CAS: 158681-13-1

❸ DNP CAS: 119-26-6

 

(2) Burning Fat

Fat burning weight loss drugs can assist fat loss by minimizing cravings, enhancing metabolism, and maintaining a healthy appetite. They can also maximize workout potential by boosting energy and focus. Such drugs include:

❶ Synephrine CAS: 94-07-5

❷ DMAA/1,3-Dimethylpentylamine CAS: 13803-74-2

 

(3) Zlepšite trávenie

Tieto lieky na zníženie telesnej hmotnosti pracujú tým, že narúšajú schopnosť tráviaceho systému absorbovať konkrétne živiny v potravinách. Napríklad je známe, že Orlistat blokuje rozklad tukov a preto zabraňuje vstrebávaniu tuku. Niektoré ďalšie doplnky boli aplikované pri znižovaní kalorickej absorpcie a inhibícii trávenia. V tomto príspevku budeme diskutovať o nasledujúcich liekoch:

❶ Orlistat CAS: 96829-58-2

❷ Cetilistat CAS: 282526-98-1

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3.The 3 Most Popular Weight Loss Powder In Market

(1) Orlistat CAS: 96829-58-2

Orlistat je silný inhibítor pankreasu a žalúdočnej lipázy. Všetky diétne triglyceridy sa metabolizujú pomocou pankreatických a žalúdočných lipáz. Lipázy enzymaticky rozkladajú triglyceridy na voľné mastné kyseliny, ktoré sa neskôr môžu absorbovať v tenkom čreve. Inhibítory žalúdočnej a pankreatickej lipázy tvoria väzby s pankreatickými a žalúdočnými lipázami v lúmenoch tenkého čreva a žalúdka, čo tieto enzýmy nedokáže správne fungovať.

Prostredníctvom inhibície pôsobenia týchto lipáz sa inhibuje aj digescia tukov v strave a triglyceridy sa vylučujú vo výkaloch. Liek na úbytok hmotnosti Orlistatu zabraňuje tomu, aby okolo 30 percentuálny podiel výživových tukov z jedla bol absorbovaný do systému ľudského tela (keď 30 percenta energie v jedle je dodávaná triglyceridmi). Priemerné zníženie hmotnosti po jednom roku s kombináciou lieku Xenical (orlistat) a zmenami v životnom štýle je okolo obrovského množstva 8.5 kg.

Spolu s redukciou absorpcie diétnych triglyceridov bol nájdený prášok na zníženie telesnej hmotnosti orlistatu:

  • Have a positive effect on blood pressure;
  • Reduce cholesterol absorption and therefore cholesterol levels (together with LDL cholesterol);
  • Enhance insulin resistance; and
  • Boost glycaemic control.

It is widely thought that orlistat’ s gastrointestinal adverse effects act in a similar way to negative reinforcement, which encourages those on this medication to adhere strictly to a low-fat diet.

 

(2) Cetilistát CAS: 282526-98-1

Cetilistat is an orally active, novel, pancreatic and gastrointestinal lipase inhibitor. Cetilistat weight loss drug is a drug manufactured to treat obesity. It functions in a similar manner as the drug discussed earlier known as Xenical (orlistat) by controlling pancreatic lipase, the enzyme which breaks down triglycerides in our intestine. Without these enzymes, triglycerides from our food are prevented from being digested into free fatty acids that can be absorbed and are removed from the body undigested.

V klinických štúdiách zahŕňajúcich obéznych pacientov bez diabetes typu 2 a u obéznych pacientov žijúcich s diabetom typu 2. Keď bol prášok na zníženie telesnej hmotnosti Cetilistat podávaný počas 12 týždňov, výrazne znížil telesnú hmotnosť, celkový cholesterol, sérový lipoproteínový cholesterol s nízkou hustotou v porovnaní s placebom.

Percento obéznych pacientov, ktoré vykazovali značné zníženie základnej telesnej hmotnosti najmenej 5 percent, bolo vyššie u všetkých aktívnych zbraní v porovnaní s placebom. U diabetických pacientov s nadváhou boli hladiny HbA1c (glykozylovanej hemoglobíny) tiež výrazne znížené. Liek na zníženie hmotnosti na báze cetilistátu vykazoval mierne až mierne nežiaduce účinky, ktoré spôsobovali predovšetkým steatoreu (gastrointestinálna povaha) s incidenciou nižšou ako u orlistatu. Táto droga bola nedávno schválená v Japonsku na liečbu obezity s ďalšími komplikáciami.

 

(3) Lorcaserin HCL(Belviq) CAS: 1431697-94-7

Lorcaserin HCl drug functions to control metabolism and appetite. The drug was approved by the FDA in the year 2012 for people with a BMI of more than 30, and for patients with a Body Mass Index of 27 or more who also have high cholesterol, blood pressure, and type 2 diabetes. The drug also functions to enhance the serotonin 2CV receptor in the human brain that can assist patients to feel full after taking less. In medical trials, 38% of adults (without type 2 diabetes) lost more than 5% of their body weight, in comparison to 16% of adults treated with a placebo. Since sibutramine powder was banned in China, lorcaserin hcl powder is the best substitute in market and many suppliers who committed to the production of weight loss drugs prefer to use lorcaserin hcl powder.

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4.How To Buy Effective Weight Loss Powder Online?

Ako je zrejmé z našej podrobnej diskusie, tam je veľa liekov na chudnutie, ktoré sú odvodené od širokej škály organických zlúčenín. Zistilo sa, že väčšina týchto liekov je účinná a niektoré z nich boli schválené rôznymi jurisdikciami, ako je FDA a Japonsko, aby sa zmienili o niekoľkých, na liečbu obezity.

After spending many hours researching on weight loss drugs, we were able to identify a few 2018 World’ s Best-Selling Weight Loss Powder Supplements. These weight loss powder supplements include orlistat weight loss powder and lorcaserin weight loss powder. Unlike the crap of weight loss supplements found at any drug store, these weight loss medicines which have been prescribed by medical professionals have gone through years of testing to get a stamp of approval from the FDA and several other jurisdictions. We highly recommend that you try these drugs because they have been proven to be not only efficient but also safe to use.

You may ask how to buy effective weight loss powder orlistat powder and lorcaserin hcl powder. There are many weight loss powder suppliers online and need figure out which one is the best for you. You need pay more attention to quality of products and whether they can be shipped to you in safe, if you need purchase weight loss powder in bulk, you must know whether their supply system and whether it is stable, consider about taking sample order before bulk order, take it to test at professional 3rd-labs and check the quality. Anyway, finding high quality supplier is not easy things, you need put more time and energy on it.

To buy genius weight loss/diet drug raw powder needs to be very cautious, especially by international online shopping. There are two many sources who claims to provide genius goods but to be proved as scammers. AASraw provides and only provides genius goods. It is recognized by most of people and companies, they can provide bulk weight loss powder, such as lorcaserin hcl, orlistat, Cetilistat. The professional testing reports can be shared and it shows 98% min purity. You can talk with aasraw sales for more details online!

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FAQ

1.How does lorcaserin help you lose weight?

For weight loss, Lorcaserin works by affecting the body’s sensation of feeling full by changing serotonin levels in the brain. It is in this way that Lorcaserin can work to treat opioid addiction.

2.Is the lorcaserin hcl powder controlled?

Hoci nie je povzbudzujúcim činidlom, pravdepodobnosť, že lorcaserín spôsobí drogovú závislosť a zneužívanie. Z tohto dôvodu správa pre drogy (DEA) ju vymenovala podľa zákona o kontrolovaných látkach v zozname IV.

 

Tak ako kontrolujú dávkovanie? Vysvetlím. Predávkovanie môže byť náhodné, ale môže to byť aj úmyselné posunutie stimulácie užívateľa. S cieľom priniesť zdravý rozum môžete predpisy iba naplniť len obmedzene.

Niektoré vedľajšie účinky lorcaserínu zahŕňajú halucinácie, pocit "vysokého", sedáciu alebo eufóriu. V niektorých prípadoch niektorí pacienti, ktorí prerušili dávku, mali niektoré abstinenčné príznaky. Všetky tieto faktory sú dostatočným dôkazom toho, že liečba môže spôsobiť psychickú závislosť.

3.Is weight-loss drug lorcaserin hcl safe?

A major study has found promising results for the safety of a weight-loss drug available in the US.The study, published in the New England Journal of Medicine, says adults using the drug lorcaserin lost an average of 4kg (8.8lb) over 40 months. It says the drug, which works by suppressing appetite, does not put people at greater risk of heart issues. But experts emphasise the importance of long-term lifestyle changes in achieving effective weight loss.Lorcaserin has been available in the US for several years under the name Belviq, but it has yet to be approved for use in Europe.

4.Is Orlistat effective for weight loss?

Orlistat works by preventing the fat from the food that you eat from being absorbed into your body. This fat eventually exits the body via your faeces.

For Orlistat to work, it must be used in conjunction with other weight-loss tactics. These include a regular exercise programme and a healthy diet plan. When taken on its own, Orlistat may not reduce weight, as it doesn’t burn existing fat.If used together with additional weight loss tactics, Orlistat has been shown to be effective at aiding weight loss.

One study found that people who took Orlistat and kept to a low-calorie diet lost on average 1.25 stone (8.1kg) a year, which was 6lb (2.8kg) more than those who did not take Orlistat during the same time period. Another study found that 743 obese patients taking Orlistat for weight loss had lost on average 10.3kg of weight after one year. This is in contrast to the 6.1kg patients not taking Orlistat lost.

Iné štúdie tiež zistili, že ľudia, ktorí sa liečia týmto liečebným cyklom, môžu stratiť až 10% svojej telesnej hmotnosti za rok.

5.Who should use orlistat powder?

Orlistat for weight loss is best taken by those who struggle to lose weight through other means. Before starting Orlistat, you should first have tried losing weight through a calorie-controlled diet and exercising regularly. You should also consider quitting smoking and reducing your alcohol intake before taking the medication. After taking Orlistat for a few weeks, you can expect to see dramatic weight loss. The actual amount varies between individuals, depending on their diet and exercise regime.

6.Orlistat powder reviews: before and after

Zak (4th, Mar. 2021): This is the first weight loss plan that I have been able to stick to. I highly recommend Orlistat powder. If you don’t like the “treatment effects”, then you really watch your fat intake! I can’t say enough about Orlistat powder. I have found that I can have a variety of foods – but portion size is the key!

 

Jimmy(16th, Apr. 2020): 3 weeks so far so good since I buy orlistat powder online and try some. I am losing the weight slow which is what I want so that I don’t have the yoyo affect. STAY on your low fat diet. I ate pizza one day and followed up with two slices for breakfast and had the oily orange discharge when passing gas or during bowel movement. Yes it will let you know when you ate too much or the wrong thing. Count your calories eat plenty of vegetables and fruit. Drink water. After reading others side affects it helps me to stick with Alli because when it happens you will scratch your head with the thought UhUh, oh no, you kidding me.

 

Bob(24th, Sep. 2021): I lose 6 pounds in one week with orlistat powder.. but I eat healthy food mon thru fri: food low fat and low calories and weekend I eat anything moderate. Also, I walking 45 minutes everyday and play tennis 3 hours on sat.

As the reviews above testify, our customers’ experiences of Orlistat as a weight-loss treatment are overwhelmingly positive. Here are a few of the key factors our customer reviews of Orlistat highlighted:

♦ It is effective at helping patients lose weight

♦ It’s great for kickstarting a weight loss plan

♦ It’s useful for slow but steady weekly weight loss

♦ It’s beneficial for reducing cholesterol levels too

Overall, our customers point to Orlistat as a reliable and effective way to lose weight.

7.What is side effects of orlistat?

Common side effects of Orlistat

The most common side effects of Orlistat typically affect around one in 10 people. These include the below, but the most common side effect is headaches:

▪ Oily or fatty faeces or oily discharge from your anus — look out for oily spots on your underwear

▪ Urgent or increased bowel movements

▪ Increased flatulence, sometimes with discharge

▪ bolesti hlavy

▪ Upper respiratory tract infections (RTIs), such as colds

▪ Stomach pains or discomfort

All of these effects are temporary and should pass with time. However, if you experience them for a prolonged period of time, or they get worse, consult with your doctor immediately.

 

Less common side effects of Orlistat

The side effects of Orlistat below are less common than those listed above and include:

▪ Softer faeces

▪ Faecal incontinence

▪ Gum or teeth disorders

▪ Bloating — this is more commonly experienced by people with type 2 diabetes

▪ Irregular periods

▪ Únava

▪ Lower respiratory tract infections

▪ Rectal pain or discomfort

If you do experience any of these side effects for a prolonged period of time or your symptoms start to get worse, speak with your doctor as soon as possible.

8.How can I reduce the side effects of Orlistat?

Most side effects of Orlistat are temporary and go away with time. If your side effects do not go away, speak with your doctor as soon as possible. It is possible to reduce Orlistat’s side effects by measuring how much fat you consume in each meal.

Orlistat works by stopping fats in your food from being absorbed into the gut. It expels any unabsorbed fat through the bowels. However, Orlistat can only get rid of so much fat per meal. Consequently, if you eat a meal with more than 1-15 grams of fat, you might experience Orlistat’s side effects more frequently. To reduce the side effects of Orlistat, consume no more than 1-15 grams of fat per meal if you’re taking Orlistat 120 mg capsules.

You can also reduce Orlistat’s side effects by sticking to the correct dosage of Orlistat. Taking more than the recommended dosage of Orlistat after a meal increases its side effects, so stick to the dosage recommended.

9.Ako používať Cetilistat prášok na liečbu obezity?

Rastúca prevalencia obezity stimulovala vyhľadávanie liekov na liečbu tohto ochorenia. Boli preskúmané rôzne terapeutické stratégie vrátane:

▪ Serotonin and noradrenaline reuptake inhibitors (anorectic agents)

▪ Lipase inhibitors

▪ b 3-adrenoreceptor agonists

▪ Leptin agonists

▪ Melanocortin-3 agonists

▪ Endocannabinoid receptor antagonists

 

Cetilistat powder is a lipase inhibitor, with a similar mode of action to Roche’s anti-obesity medication orlistat powder which received regulatory approval in 1997. These drugs act in the gastrointestinal tract to inhibit lipases, enzymes involved in the breakdown of dietary fats. By inhibiting the breakdown and subsequent absorption of fats from the gut, lipase inhibitors reduce fat intake and calories, thus aiding fat loss.

10.Orlistat Powder Vs Cetilistat powder

položky Orlistat prášok Cetilistat prášok
Číslo CAS 96829 58 - 2  282526 98 - 1
Mechanizmus účinku Orlistat does not work by suppressing appetite; it reduces the amount of fats that your body absorbs from the food that you consume. Cetilistat is a gastrointestinal lipase inhibitor that blocks fat digestion and absorption, leading to reduced energy intake, and thus weight loss.
Dávkovanie 120 mg orally three times a day with each main meal containing fat. 120 mg three times a day immediately after each meal.
Nežiaduce účinky ▪ Passing gas, sometimes with oily spotting

▪ Loose stools, greasy stools, or diarrhea

▪ Frequent stools or bowel movements that are hard to control

▪ Zápcha

▪ Bolesť brucha

▪ Bloating

▪ Oily

▪ Loose stools

▪ Fecal incontinence

▪ Flatulence

▪ Abdominal Pain

▪ Soft stools

▪ Dry Mouth

 

Recenzia ☆☆☆☆ ☆☆☆

Referencie

[1] “FDA Issues Complete Response Letter for Lorcaserin New Drug Application”. 23 October 2010. Archived from the original on 24 October 2010.

[2] Higham, George (5 June 2020). “ᐅ Orlistat & Xenical: Do Weight Loss Pills Work? | e-Surgery”. e-surgery. Retrieved 9 June 2020.

[3] “Fake Alli diet pills can pose health risks”. CNN. 23 January 2010. Retrieved 24 January 2010.

[4] Yamada Y, Kato T, Ogino H, Ashina S, Kato K: Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. Horm Metab Res. 2008 Aug;40(8):539-43. doi: 10.1055/s-2008-1076699. Epub 2008 May 21.

[5] Devarajan, Uma (1 March 2009). “Fatty issues”. The Deccan Chronicle. Retrieved 26 November 2009.

[6] Stylized with a lowercase a on the packaging, and a bar over the i (that is, “allī”), but capitalized conventionally in the manual.

[7] Pollack A (16 September 2010). “F.D.A. Panel Rejects Diet Pill”. The New York Times. Archived from the original on 17 July 2011.

[8] “Lorcaserin Use During Pregnancy”. Drugs.com. 4 November 2019. Retrieved 14 January 2020.

[9] Padwal, R (2008). “Cetilistat, a new lipase inhibitor for the treatment of obesity”. Current Opinion in Investigational Drugs. 9 (4): 414–21. PMID 18393108.

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